ABCC10 (MRP7)-mediated multidrug resistance in cancer.
Zhe-Sheng Chen. Seminar at Central South University, Aug. 11,
Changsha, China.
ABCC10 (MRP7)-mediated multidrug resistance in cancer.
Zhe-Sheng Chen. Invited speaker in Congress on Advances in
Personalized Chemotherapy for Cancer and Anticancer Drug Research,
Aug. 7-8, 2010, Guangzhou, China.
ABCC10 (MRP7)-mediated multidrug resistance in cancer.
Zhe-Sheng Chen. Invited speaker at Hongkong University of Chinese,
July. 30, Hongkong, China.
BCR-Abl tyrosine kinase inhibitor Nilotinib (Tasigna®) reverses
ABCB1/Pgp- anABCG2/BCRP -mediated multidrug resistance. Amit
K. Tiwari, Kamlesh Sodani, Sirong Wang, Ye-Hong Kuang, Xiang Chen,
Wen Deng, Kevin Chen, Charles R. Ashby Jr., Zhe-Sheng Chen 101st
American Association for Cancer Research (AACR), April 17~21, 2010,
Washington D.C., USA.
Sunitinib reverses ABCG2/BCRP-mediated multidrug resistance by
inhibiting its efflux activity
Chun-ling Dai, Yong-ju Liang, Yan-sheng Wang, Amit K. Tiwari,
Yan-yan Yan, Fang Wang, Zhe-Sheng Chen, Xiu-zhen
Tong, Li-wu Fu, 101st American Association for Cancer Research
(AACR), April 17~21, 2010, Washington D.C., USA.
Lapatinib, erlotinib, imatinib and nilotinib are potent reversal
agents for MRP7 (ABCC10)-mediated multidrug resistance. Kamlesh
Sodani, Ye-Hong Kuang, Tong Shen, Saurabh Vispute Amit K. Tiwari,
Yu Lei, Jeferson Lee, Xiang Chen, Charles R. Ashby Jr., Zhe-Sheng
Chen. 101st American Association for Cancer Research (AACR), April
17~21, 2010, Washington D.C., USA.
Lapatinib, erlotinib, imatinib and nilotinib are potent reversal
agents for MRP79ABCC10)-mediated multidrug resistance.
Kamlesh Sodani, Ye-Hong Kuang, Tong Shen, Thomas M. D’Ambra, Amit
K. Tiwari, Yu Lei, Jeferson Lee, Xiang Chen, Charles R. Ashby Jr,
Zhe-Sheng Chen. Oral presentation at 6th North American ABC
workshop. Sept. 24-25, 2009, NCI-Frederick, Maryland.
Marine sponge-derived sipholane triterpenoids reverse
P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer
cells. Ioana Abraham, Sandeep Jain, Chung-Pu Wu, Yehong
Kuang, Zhi Shi, Xiang Chen, Wen Deng, Liwu Fu, Suresh V. Ambudkar,
Khalid El Sayed, Zhe-Sheng Chen. Oral presentation at 6th
North American ABC workshop. Sept. 24-25, 2009, NCI-Frederick,
Maryland.
Reversal of ABCB1-mediated multidrug resistance in leukemia cells
by lapatinib in vitro and ex vivo. Chun-ling Dai, Yan-Sheng
Wang, Xiu-Zheng Tong, Yongju Liang, Zhe-Sheng Chen, Suresh V.
Ambudkar, Susan Bates, Liwu Fu. poster at 6th North American ABC
workshop. Sept. 24-25, 2009, NCI-Frederick, Maryland.
Nilotinib (AMN107, Tasigna) reverses multidrug resistance by
inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR
transporters. Amit K. Tiwari, Kamlesh Sodani, Sirong Wang,
Ye-Hong Kuang, Xiang Chen, Kevin Chen, Charles R. Ashby Jr.,
Zhe-Sheng Chen. poster at 6th North American ABC workshop.
Sept. 24-25, 2009, NCI-Frederick, Maryland.
ABCC10 (MRP7)-mediated multidrug resistance in cancer.
Zhe-Sheng Chen. Invited speaker in LCB Seminar, Division of Basic
Sciences, NCI, NIH Sept 2009, Washington DC. USA.
http://lcb.nci.nih.gov/Seminar%20schedule.html
Tyrosine kinase inhibitors as modulators of MDR in cancer.
Zhe-Sheng Chen. Invited speaker in Peking University Institute of
Molecular Medicine, July 9, 2009, Beijing, China.
Tyrosine kinase inhibitors as modulators of MDR in cancer.
Zhe-Sheng Chen. Invited speaker in National Center for Nanoscience
and nanotechnology, July 9, 2009, Beijing, China.
Tyrosine kinase inhibitors as modulators of MDR in cancer.
Zhe-Sheng Chen. Invited speaker in National Engineering Research
Center for R&D TCM Multi-ingredient Drugs, July 10, 2009,
Beijing, China.
Tyrosine kinase inhibitors as modulators of MDR in cancer.
Zhe-Sheng Chen. Invited speaker in Institute of Medicinal
Biotechnology Chinese Academy of Medical Sciences & Peking
Union Medical College, July 10, 2009, Beijing, China.
Tyrosine kinase inhibitors as modulators of MDR in cancer.
Zhe-Sheng Chen. Invited speaker in Central South University Xianya
School of Medicine, July 13, 2009, Changsha, China.
Tyrosine kinase inhibitors as modulators of MDR in cancer.
Zhe-Sheng Chen. Invited speaker in Cancer Center of Sun Yat-Sen
University, July 21, 2009, Guangzhou, China.
Marine sponge-derived sipholane triterpenes reverse P-glycoprotein
(ABCB1)-mediated multidrug resistance in cancer cells. Ioana
Abraham, Sandeep Jain, Chung-Pu Wu, Yehong Kuang, Jefferson Kevin
Lee, Xiang Chen, Khalid El Sayed, Suresh V. Ambudkar, Zhe-Sheng
Chen. 100th American Association for Cancer Research (AACR), April
18~22, 2009, Denver, Colorado, USA.
RNA interference targeting the CD147 induces apoptosis of
multi-drug resistant cancer cells related to XIAP depletion.
Ye-Hong Kuang, Xiang Chen, Juan Su, Li-Sha Wu, Li-Qiu Liao, Dai Li,
Takuro Kanekura, Zhe-Sheng Chen. 100th American Association
for Cancer Research (AACR), April 18~22, 2009, Denver, Colorado,
USA.
Lapatinib could reverse ABCB1 and ABCG2 mediated-multidrug
resistance in Vitro, ex-vivo and in Vivo but increase exposure of
chemotherapeutic agent. Chun-ling Dai, Yan-sheng Wang, Amit K.
Tiwari, Chung-pu Wu, Xiao-dong Su, Si-rong Wang, Dong-geng Liu,
Charles R. Ashby Jr., Yan Huang, Robert W. Robey, Yong-ju Liang,
Li-ming Chen, Cheng-jun Shi, Suresh V. Ambudkar, Zhe-sheng Chen,
Liwu Fu. 100th American Association for Cancer Research
(AACR), April 18~22, 2009, Denver, Colorado, USA.
TYROSINE KINASE INHIBITORS AS MODULATORS OF MULTIDRUG RESISTANCE IN
CANCER. Zhe-Sheng Chen Amit K. Tiwari, Zhi Shi,
Chun-Ling Dai, Suneet Shukla, Chung-Pu Wu, Si-Rong Wang, Ioana
Abraham, Kamleshkumar Sodani, Charles R. Ashby Jr, Yehong Kuang,
Robert W. Robey, Li-Wu Fu, Susan E. Bates, Suresh V. Ambudkar. Oral
presentation at Abcam Multidrug Resistance & ABC Transporters
Conference. Nov. 5th, Baltimore, Maryland USA (Dr. Chen served as a
committee member of “best poster award” at the Abcam conference).
http://www.abcam.com/index.html?pageconfig=resource&rid=11531&source=pagetrap
Differential Effects of the EGFR Tyrosine Kinase Inhibitor AG1478
on the Function of ABCB1 and ABCG2. Amit Tiwari, Zhi Shi,
Suneet Shukla, Robert W. Robey, In-Wha Kim, Susan E. Bates,
Qiu-Sheng Si, Curtis S. Goldblatt, Smitaben Parmar, Ioana
Abraham,Yang-Min Chen, Li-Wu Fu, Suresh V. Ambudkar, Zhe-Sheng
Chen. Oral presentation at 5th North American ABC workshop. Sept.
24-26, 2008, NCI-Frederick, Maryland.
Cepharanthine Is a Potent Reversal Agent for MRP7-Mediated
Multidrug Resistance. Tong Shen, Ying Zhou, Elizabeth Borge-Hopper,
Xiao-Cong Huang, Zhi Shi, Tatsuhiko Furukawa, Shin-Ichi
Akiyama, Kamlesh Sodani, Charles R. Ashby, Jr., Gary D. Kruh, and
Zhe-Sheng Chen. Oral presentation at 5th North American ABC
workshop. Sept. 24-26, 2008, NCI-Frederick, Maryland.
Reversal of Multidrug Resistance by Lapatinib. Chun-Ling Dai,
Amit K. Tiwari, Chungpu Wu, Xiao-Dong Su, Dong-Geng Liu, Yan Huang,
Yong-Ju Liang, Li-Ming Chen, Cheng-Jun Shi, Charles Ashby Jr.,
Zhe-Sheng Chen, Syresh V. Ambudkar, Jian-Ye Zhang, Robert W. Robey,
Susan E. Bates, and Li-wu Fu. Oral presentation at 5th North
American ABC workshop. Sept. 24-26, 2008, NCI-Frederick,
Maryland.
Differential Effects of the EGFR Tyrosine Kinase Inhibitor AG1478
on the Function of ABCB1 and ABCG2. Zhi Shi, Amit Tiwari,
Smitaben Parmar, Suneet Shukla, Robert W. Robey, In-Wha Kim, Susan
E. Bates, Qiu-Sheng Si, Curtis S. Goldblatt, Ioana Abraham, Nick
Shao,Yang-Min Chen, Annie Zhang, Li-Wu Fu, Suresh V. Ambudkar,
Zhe-Sheng Chen. 99th American Association for Cancer Research
(AACR), April 12~16, 2008, San Diego, CA, USA.
Reversal of ABCB1- and ABCG2-mediated MDR by erlotinib (tarceva,
OSI-774). Zhi Shi, Xing-Xiang Peng, In-Wha Kim, Suneet
Shukla, Qiu-Sheng Si, Robert W. Robey, Susan E. Bates, Sirong Wang,
Christine Chim, Tong Shen, Charles R. Ashby, Jr, Li-Wu Fu, Suresh
V. Ambudkar, Zhe-Sheng Chen 99th American Association for Cancer
Research (AACR), April 12~16, 2008, San Diego, CA, USA.
Multidrug Resistance and Its Reversal. Zhe-Sheng (Jason)
Chen, Zhi Shi, Xing-Xiang Peng, In-Wha Kim, Suneet Shukla,
Sandeep Jain, Qiu-Sheng Si, Robert W. Robey, Li-Wu Fu, Diaa
Youssef, Susan E. Bates, Suresh V. Ambudkar, Khalid El Sayed.
Invited speaker (lecture, co-chair) at 12th World Congress on
Advances in Oncology and 10th International Symposium on Molecular
Medicine, 11-13 October, 2007, Creta Maris, Hersonissos, Crete,
Greece
Erlotinib (Tarceva, OSI-774) Antagonizes ABCB1 (P-glycoprotein)-
and ABCG2-mediated Drug Resistance. Zhi Shi, Xing-Xiang Peng,
In-Wha Kim, Suneet Shukla, Qiu-Sheng Si, Robert W. Robey, Susan E.
Bates, Tong Shen, Charles R. Ashby, Jr, Li-Wu Fu, Suresh V.
Ambudkar, Zhe-Sheng Chen, The 4th North American ABC
workshop, Oct 4~5, 2007, Washington DC. MD, USA.
Development of Sipholane Triterpenes as Modulators of Multidrug
Resistance in Cancer. Tong Shen, Amit Tiwari, Zhi Shi, Ioana
Abraham, Xing-Xiang Peng, In-Wha Kim, Sandeep Jain, Charles Ashby,
Li-Wu Fu, Diaa Youssef, Khalid El Sayed, Suresh V. Ambudkar,
Zhe-Sheng Chen. Oral presentation at the 4th North American ABC
workshop, Oct 4~5, 2007, Washington DC. MD, USA.
Up-regulation of MRP4 and down-regulation of influx transporters in
human leukemic cells with acquired resistance to
6-mercaptopurine. Amit Tiwari, Xing-Xiang Peng, Zhi Shi,
Vijaya L.Damaraju, Xiao-Cong Huang, Gary D. Kruh, Hsiang-Chun Wu,
Ying Zhou, Liwu Fu, Carol E. Cass, Zhe-Sheng Chen. Oral
presentation at the 4th North American ABC workshop, Oct 4~5,
2007, Washington DC. MD, USA.
Sipholenal A, a marine-derived sipholane triterpene, potently
reverses P-glycoprotein-mediated multidrug resistance in cancer
cells. Zh Shi, Sandeep Jain, In-Wha Kim, Xing-Xiang Peng,
Ioana Abraham, Li-Wu Fu, Diaa T. A., Youssef, Khalid El Sayed.,
Suresh V. Ambudkar, and Zhe-Sheng Chen. 98th Annual Meeting
American Association for Cancer Research April 14~18., 2007,
Los Angeles, CA, USA
Characterization of chronic myeloid leukemia cell lines with
acquired drug resistance to 6-MP and imatinib. Xing-Xiang
Peng, Zhi-Shi, Xiaocong Huang, Gary D. Kruh., Hsian-Chun Wu.,
Smitaben Parmar., Ying Zhou, Ioana Abraham., and Zhe-Sheng Chen.
98th Annual Meeting American Association for Cancer Research
April 14~18., 2007, Los Angeles, CA, USA
Human multidrug resistance protein 7 (ABCC10) is a resistance
factor for nucleotide analogs and epothilone B. Elizabeth A.
Hopper-Borge, Xiu Xu, Zhe-Sheng Chen, Gary Kruh. 98th Annual
Meeting American Association for Cancer Research April 14~18.,
2007, Los Angeles, CA, USA
Characterization of a human T cell with acquired drug resistance to
6-mercaptopurine. Xing-Xiang Peng, Ying Zhou, Vijaya L. Damaraju,
Carol E. Cass, Gary D. Kruh, Zhe-Sheng Chen.97th Annual Meeting
American Association for Cancer Research. April 1-5, 2006,
Washington DC. USA.
Interacting binding sites in Human Multidrug Resistance Protein 8
(MRP8, ABCC11) Zhe-Sheng Chen, Yanping Guo, Martin G. Belinsky,
Elena Kotova, and Gary D. Kruh. 96th Annual Meeting
American Association for Cancer Research. April16-20, 2005,
Anaheim, Orange County, CA. USA.
Analysis of the in vivo functions of Mrp3 using knockout mice,
Martin G. Belinsky, Paul A. Dawson, Irina Shchaveleva, Lisa I.
Nain, Renxue Wang, Victor Ling, Zhe-Sheng Chen, Alex Grinberg,
Heiner Westphal, Andres Klein-Szanto, Anthony Lerro, and Gary D.
Kruh. 96th Annual Meeting American Association for
Cancer Research. April16-20, 2005, Anaheim, Orange County, CA.
USA.
Transport properties of human multidrug resistance protein 8 (MRP8,
ABCC11), A new ABC Transporter. Zhe-Sheng Chen. Invited
speaker at Queens University, August 5, 2004,
Kingston, Canada (Committee chair: Professor
Susan Cole, the discover of MRP1)
Functional Studies on multidrug resistance protein 8 (MRP8, ABCC11)
Zhe-Sheng Chen. Invited speaker at Shantou University, June
27, 2004, Shantou, Guangdong, China
Multidrug resistance proteins (MRPs): Drug Resistance and Substrate
Specificity, Zhe-Sheng Chen. Invited speaker at Cancer
Center, Sun Yat-Sen University, June 22, 2004,
Guangzhou, China
Functional Studies on multidrug resistance protein 8 (MRP8,
ABCC11), A new ABC transporter, Zhe-Sheng Chen. Invited
speaker at St. John’s University, April 6, 2004, Jamaica, NY.
USA
Multidrug resistance proteins (MRPs):Drug resistance, Substrate
specificity and regulation, Zhe-Sheng Chen. Invited speaker
at The University of Louisiana at Monroe. March 9, 2004,
Monroe, LA. USA.
Transport of Amphipathic Anions by Human Resistance Protein 8
(MRP8, ABCC11) Zhe-Sheng Chen, Yanping Guo, Martin G. Belinsky, and
Gary D. Kruh. 95th Annual Meeting American Association
for Cancer Research. March 27-31, 2004, Orlando, FL. USA.
Analysis of the contribution of mrp3 to in vivo chemosensitivity
using knock out mice, Martin G. Belinsky, Irina Shchaveleva,
Zhe-Sheng Chen, Alan C. Sartorelli and Gary D. Kruh Annual Meeting
American Association for Cancer Research. March 27-31, 2004,
Orlando, FL. USA. (Minisymposium)
Transport of MTX and 17-Estradiol 17-( -D-glucuronide) by ABCG2
(BCRP/MXR) : Effects of acquired mutations at amino acid position
482 and polyglutamylation on MTX transport Zhe-Sheng Chen, Robert
W. Robey, Martin G. Belinsky, Irina Shchaveleva, Xaio-Qin Ren,
Yoshikazu Sugimoto, Douglas D. Ross, Susan E. Bates, and Gary D.
Kruh 94th Annual Meeting American Association for Cancer Research.
July 11-14, 2003, Washington DC. USA.
Characterization of the Transport Properties of Multidrug
Resistance Protein 7 (MRP7, ABCC10) Zhe-Sheng Chen, Elizabeth
Hopper-Borge, Martin G. Belinsky, Irena Shehaveleva, and Gary D.
Kruh. 94th Annual Meeting American Association for Cancer Research.
July 11-14, 2003, Washington DC. USA (Scholar-in-training
award’s abstract)
Transport of MTX and 17-Estradiol 17-( -D-glucuronide) by ABCG2
(BCRP/MXR): Effects of acquired mutations at amino acid position
482 and polyglutamylation on MTX transport, Zhe-Sheng Chen, Robert
W. Robey, Martin G. Belinsky, Irina Shchaveleva, Xaio-Qin Ren,
Yoshikazu Sugimoto, Douglas D. Ross, Susan E. Bates, and Gary D.
Kruh, 4th FEBS Advanced Lecture Course “ATP-Binding Cassette
Proteins: From genetic disease to multidrug resistance”. March 1-9,
2003, Gosau, Austria. (Plenary Talks)
Analysis of Methotrexate and folate transport by MRP4 (ABCC4): MRP4
is component of the methotrexate efflux system, Zhe-Sheng Chen, Kun
Lee, Susan Walther, Rebecca Blanchand-Raftogianis, Michihiko,
Kuwano, Hao Zeng and Gary D. Kruh, 93 rd Annual Meeting American
Association for Cancer Research. April 6-10, 2002, San Francisco,
CA. USA
Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide
by MRP4: Resistance to anti-cancer purine analogs, Zhe-Sheng Chen,
Kun Lee, and Gary D. Kruh, AACR-NCI-EORTC international conference:
Molecular Targets and Cancer Therapeutics: Discovery, Biology, and
Clinical Applications. Oct.29-Nov.2, 2001, Miami Beach, Florida.
USA.
Transport of Methotrexate and Folates by MRP3 and MRP1:
Effect of polyglutamylation on methotrexate transport. Hao Zeng,
Zhe-Sheng Chen, Philip A.Rea, and Gary D. Kruh, 92nd Annual Meeting
American Association for Cancer Research. March 24-28, 2001, New
Orleans, LA. USA.
Human cMOAT and multidrug resistance. Zhe-Sheng Chen
Invited speaker in Laboratory of cell biology, Division of Basic
Sciences, NCI, NIH November 16, 1999, Washington DC.
USA.
Effect of multidrug resistance reversing agents on the transporting
activity of human canalicular multispecific organic anion
transporter (cMOAT). Chen, Z.S., Kawabe, T., Ono, M., Sumizawa, T.,
Furukawa,T., Uchiumi, T., Wada, M., Kuwano, M., and Akiyama,
S.AACR-NCI-EORTC meeting. November 16-19, 1999, Washington,
DC.USA
An active efflux system for anticancer drugs and heavy metals in
cisplatin-resistant KCP-4 cells Chen, Z.S., Mutoh, M., Sumizawa,
T., Furukawa,T., Tani, A., Kuwano, M., and Akiyama, S. 90th Annual
Meeting American Association for Cancer Research. April, 1999,
Philadelphia, PA, USA.
Transfection of human cMOAT/MRP2 cDNA induces altered sensitivity
to anticancer agents and membrane transport of glutathione
conjugates Kawabe, T., Wada, M., Nakamura, T., Uchiumi, T., Ono,
M., Chen, Z.S., Akiyama, S., and Kuwano, M.n 90th Annual Meeting
American Association for Cancer Research. April, 1999,
Philadelphia, PA, USA. (Young Investigator award's abstract)
LRP is involved in multiple drug resistance. Kitazono, M.,
Sumizawa, T., Takebayashi, Y., Tani, A., Chen, Z.S., Furukawa, T.,
Aikou, T., Akiyama, S. 90th Annual Meeting American Association for
Cancer Research. April, 1999, Philadelphia, PA, USA. (Young
Investigator award's abstract)
An efflux pump for heavy metals different from MRP and cMOAT in
cisplatin-resistant human KB carcinoma cells. Chen, Z.S., Sumizawa,
T., Furukawa, T., Haraguchi, M., Tani, A., and Akiyama, S. 5th Hong
Kong International Cancer Congress. November 8-11, 1998. Hong Kong,
China (Young Investigator award's abstract) (Speech)
Cisplatin Resistance. Akiyama, S., Chen, Z.S., Sumizawa, T.,
Furukawa, T., Kuwano, M. Symposium. 5th Central European Lung
Cancer Conference. September 13-16, 1998, Prague, Czech
Republic.
Induction of MRP and LRP by differentiating agent, sodium butyrate.
Kitazono, Takebayashi, Y., Nagayama, S., Tani, A., Chen, Z.S.,
Furukawa, T., M., Sumizawa, T., Takao, S., Aikou, T., and Akiyama,
S. The 89th Annual Meeting American Association for Cancer
Research, April, 1998, New Orleans, LA USA.
ABC transporters and Camptothecin drug resistance. Chen, Z. S.
Invited speaker at Shantou University, March 20, 1998, Shantou,
Guangdong, China
Reversal of MRP-associated drug resistance by the pyridine analog,
PAK-104P. Chuman, Y., Chen, Z.S., Sumizawa, T., Seto, K., Furukawa,
T., Haraguchi, M., Tani, A., Shudo, N., Yamada, K., Akiyama, S.,
and Aikou, T. The 88th Annual Meeting American Association
for Cancer Research. April, 1997, San Diego, CF, USA.
The role of glutathione in cisplatin resistant KCP-4 cells. Chen,
Z.S., Mutoh, M., Sumizawa, T., Chuman, Y., Furukawa, T., Haraguchi,
M., Tani, A., Handa, K., Saijo, N., and Akiyama, S. The 88th Annual
Meeting American Association for Cancer Research, April, 1997, San
Diego, CF, USA.