2011 Doctoral Seminar Series College of
Pharmacy & Allied Health Professions- “Drug Metabolism and Pharmacokinetics in Drug
Discovery and Development”
Evaluation of Drug Metabolism and Pharmacokinetics (DMPK)
properties are an important part in the development of a new
chemical entity (NCE). In the preclinical stage of drug
development, DMPK studies are routinely evaluated in both animal
and human in vitro models and in vivo animal species. The
presentation will focus on DMPK studies conducted in early drug
discovery stage to select NCE with potential to be developed as a
clinical candidate (CC). With selection of the CC,
confirmatory DMPK studies are conducted to assess ability of the CC
to alter the disease state as proof of concept (POC) studies,
including human mass balance (ADME) studies. Human ADME study
evaluates the metabolites generated in humans and determines the
safety profile of the metabolites (MIST*guidelines by FDA) in
various preclinical animal species. Such ADME studies of a
new drug molecule conducted in rats, dogs and in humans will be
presented with MIST guidelines in perspective.
Parnali Chatterjee, Ph.D., Assistant Professor - Department of
Pharmaceutical Sciences, St. John’s University
Hosted by Lin L. Mantell, M.D., Ph.D.
Seminar sponsored by the Department of
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Monday September 26, 2011
5:00 pm to 6:05 pm
D’Angelo Center, Room 206, Queens Campus